Gacci M, Coppi M, Baldi E, Sebastianelli A, Zaccaro C, Morselli S et al. Clinical characteristics and results of semen tests among men with coronavirus disease 2019. Absence of SARS-CoV-2 in semen of a COVID-19 patient cohort. When you decide it’s time to undergo a frozen embryo transfer, it’s important to prepare your uterus for implantation through the proper drugs and behaviors. Guo L, Zhao S, Li W, Wang Y, Li L, Jiang S, et al. For patients 35 or younger, there is a 60 pregnancy rate per embryo transfer, whereas women over the age of 40 have a 20 pregnancy rate per embryo transfer. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Zou X, Chen K, Zou J, Han P, Hao J, Han Z. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, Winter H, Meister M, Veith C, Boots AW, Hennig BP, Kreuter M, Conrad C, Eils R. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. Pending further studies, in cases of FET cycles with limited number of embryos, postponing embryo transfer for at least 60 days following recovery from COVID-19 might be considered when feasible. In FET cycles of patients with past SARS-CoV-2 infection, in which oocytes were retrieved prior to infection, decreased pregnancy rates were observed, specifically in patients who recovered less than 60 days prior to embryo transfer. Logistic regression applied on the subgroup of women infected in proximity to the transfer further strengthened the univariate results, with COVID-19 remaining a significant parameter (p = 0.005, OR 0.072, 95% CI 0.012-0.450). In a logistic regression model, infection was a significant variable (p = 0.05, OR 0.325, 95% CI 0.106-0.998). Stratification by time from SARS-CoV-2 infection to transfer into ≤ 60 and > 60 days revealed a difference in pregnancy rates, with women in the COVID group having lower pregnancy rates if infected in proximity to the transfer (21% vs. Pregnancy rates were 29% and 49% respectively (p = 0.070). Demographic and cycle characteristics and outcomes were compared.įorty-one recovered women and 41 controls were included. Controls were SARS-CoV-2 non-diagnosed, non-vaccinated women matched by age, number, and day of embryo transfer. To study the effect of SARS-CoV-2 infection on pregnancy rates in frozen embryo transfer (FET) cycles.Ī retrospective cohort study including women under the age of 42 with documented SARS-CoV-2 infection up to 1 year prior to treatment, undergoing FET cycles in the first half of 2021, with transfer of embryos generated prior to the infection.
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